What really happens when you mix medications? | Russ Altman

If you take two different medications for two different reasons, here’s a sobering thought: your doctor may not fully understand what happens when they’re combined, because drug interactions are incredibly hard to study. In this fascinating and accessible talk, Russ Altman shows how doctors are studying unexpected drug interactions using a surprising resource: search engine queries.

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30 gedachten over “What really happens when you mix medications? | Russ Altman”

  1. How about using chemistry to learn more about the chemical interactions of drugs that you're interested in? That along with informatics should be useful. Not simple though, not simple

  2. My best friend's dad died when she was like 8 because he had pneumonia and then he accidentally mixed medications that had a chemical reaction and killed him.

  3. how? i bet big pharma is on it already. data collection… these databases he's talking about are, even in the best of cases, so woefully unreliable, with blanks in data in crucial points that examining requires hundreds/thousands of vital research hours. Big data has many huge implications. but data collection isn't even thought about. the point I'm making in a book I'm writing on this topic

  4. Maybe the question should be, why would you need so many drugs?
    see – Adverse Childhood Experiences study by Kaiser Permanente

  5. Who is going to type in 9 different drugs and a side effect into a search query? I can't see most people typing in more than 1 drug and a side effect or series of side effects at a time. If you as doctors really have no idea what happens when 9 drugs interact with one another, maybe its time to rethink the approach of using "the hammer" as a first line treatment, let alone the one and only treatment for every situation and be more open to adding other tools to your toolbox.

    The situation always seems to play out like this. Get sick, go see a western medical doctor, doctor tosses drug at you for problem. Some time passes, get sick again, go see the doctor(same or another one) to treat that new problem, doctor tosses drug at you to treat that problem. Eventually you get sick, go see the doctor, they ask what meds you are on and for some reason are shocked when you are on like 5 different meds face palm..

  6. He is right, media nowadays can be used to check for things like drug interactions. But he has a problem: He just got lucky with those 2 drugs. There are millions of drugs and many of them don't interact. He can't just try out all the interaction combinations, that takes hundreds of years, and not only that, new drugs come out everyday. So unless he has a method of knowing which drugs are more likely to interact with eachother (those who aren't already proven to interact, he is wrong by saying there are no studies of drugs interactions previous to his'), he will be blindly guessing for interactions his whole life.

  7. This is a great video. I was looking for how they interacted: where in the body, why, train of events etc., but I found something almost as interesting

  8. Don't we call this 'synergistic' or 'antagonistic' effect in science? Or, is there another proper term for this effect?

  9. Ah, loved this talk! I have always wondered about this topic for many different reasons, and from a personal story! Medications in general can have many different and potential risks to them. One medication alone can have anywhere from 1-20+ different types of side effects with it. The more medications you add into the mix, the more complicated things can get.
    Altman made a comment that if a patient is on a type of medication, then becomes depressed, a doctor may put that patient on an anti-depressant drug. Sounds great, and could get the job done. Right? Not necessarily. Do those two drugs clash? How will they react with one another? Which makes me think of my mother.
    Depression runs in my family. My mom has had depression for as long as I can remember, and a couple of my aunts and uncles have also suffered from depression as well. There was one point in my life where I can remember that my mother was taking 6 different pills a day. All prescribed to her by the same doctor. She didn't think anything of it, rather than that is what her doctor prescribed, so that is what she was taking. However, one pill alone was 875 mg, which is a lot. My mother is a small woman. Just above 5 feet tall, and around 105 pounds, nothing big by any means. Until she was always tired, taking multiple naps throught the day (which was unlike her), and occasionally getting sick a couple times a week. I noticed, but didn't say anything. Until my dad had enough of it, and took her to the doctors. After 7 months of taking 6 pills a day, the doctor cut it back to just two. I had my mother back. She was fine, full of energy and life. So, here is my question, why 6? Six took my mother away, two I gained my mother back. Why do doctors always think more is better? Clearly, they did not know what mixing all of these would do to her tiny body, yet, I thought it was excessive to begin with.
    More research and funding needs to go into this topic because it is something almost everyone goes through. I alone take two different pills each day. My brother takes two, and so does my mom. However, there are more people out in society that probably take a handful more than just two a day, that could be potentionaly putting harm to their body by doing so.
    Overall, I agree with what Altman is saying when it comes to this topic on mixing medications. More studying needs to go into it, and more eyes need to be focused on this topic.

  10. I'm looking for a video where it talks about what happens if you take opioids and an amphetamine like heroin and meth

  11. I’m trynna make my Abusive dad get really sick ( not tryna kill him) but sick b/c when he’s sick he’s not abusive he yells,beats us with punches and kicks like we’re grown men and I’m tired of it and this guy takes pain medication anyone know any common medication mix or common house items with honey (he drinks honey) to get him sick fast and painfully sick

  12. Poison the patient with 11 drugs a day, because he had a sprained back. Those are Medical Procedures for the sucker.

  13. Back in 2017, the United Kingdom government announced an initiative to take on 250 pharmacists.
    They were going to be tasked with initially going into Nursing and Care Homes to check medication interactions. I thought that was a perfect idea. To reduce harmful medication interactions to improve quality of life. Also reduce the NHS burden for over 65's as all meds are free for them.
    Nothing has been reported anywhere since that announcement.
    Huge drug companies do not care about interactions between medications, only that you live long enough to take their meds for years.

    Then it was announced that any over the counter meds for skin problems, gluten allergy, many other allergies, urine infections, thrush, cystitis and a few others would no longer be prescribed. Each person is supposed to self diagnose without any testing.
    How dangerous do we think that is?
    Especially for the immunocompromised or allergy sufferers.
    Common sense is always bypassed by those with profits in mind.

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